The content discusses a novel approach to accessing high-energy carbene intermediates, which are valuable but often challenging to generate using classical methods. The key innovation is a metallaphotoredox platform that enables carbene formation through a two-step radical addition and redox-promoted α-elimination process.
The authors demonstrate the versatility of this strategy by showcasing its application to a range of carbene-mediated transformations, including cyclopropanation and σ-bond insertion into N–H, S–H, and P–H bonds. Importantly, these reactions can be carried out using abundant and bench-stable starting materials such as carboxylic acids, amino acids, and alcohols, overcoming the limitations of traditional carbene generation methods.
The content highlights how this metallaphotoredox approach represents a general solution to the challenge of harnessing carbene reactivity for complex molecule synthesis, enabling the construction of diverse molecular scaffolds from readily available feedstocks.
Para Outro Idioma
do conteúdo original
www.nature.com
Principais Insights Extraídos De
by Benjamin T. ... às www.nature.com 06-06-2024
https://www.nature.com/articles/s41586-024-07628-1Perguntas Mais Profundas