
IL-6シグナリングは、腱の修復性線維芽細胞の活性化と損傷部位への移動を促進し、腱疾患の特徴を悪化させる。


coremsg

Tendinopathies are debilitating diseases currently increasing in prevalence and associated costs. There is a need to deepen our understanding of the underlying cell signaling pathways to unlock effective treatments. In this work, we screen cell signaling pathways in human tendinopathies and find positively enriched IL-6/JAK/STAT signaling alongside signatures of cell populations typically activated by IL-6 in other tissues. In human tendinopathic tendons, we also confirm the strong presence and co-localization of IL-6, IL6R, and CD90, an established marker of reparative fibroblasts. To dissect the underlying causalities, we combine IL-6 knock-out mice with an explant-based assembloid model of tendon damage to successfully connect IL-6 signaling to reparative fibroblast activation and recruitment. Vice versa, we show that these reparative fibroblasts promote the development of tendinopathy hallmarks in the damaged explant upon IL-6 activation. We conclude that IL-6 activates tendon fibroblast populations which then initiate and deteriorate tendinopathy hallmarks.

### Competing Interest Statement

The authors have declared no competing interest.

IL-6 SIGNALING EXACERBATES HALLMARKS OF CHRONIC TENDON DISEASE BY STIMULATING REPARATIVE FIBROBLASTS

慢性腱疾患の特徴を悪化させるil-6シグナリング-前駆細胞の増殖と損傷部位への移動を刺激する


慢性腱疾患の特徴を悪化させるIL-6シグナリング:前駆細胞の増殖と損傷部位への移動を刺激する
