
Remodeling of the specialized extracellular matrix, termed perineuronal net, surrounding neurons in the arcuate nucleus of the hypothalamus drives insulin resistance and metabolic dysfunction in obesity and type 2 diabetes.


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Experiments in mice show that the perineural net has a key role in metabolic disease by controlling insulin access to neurons in the arcuate nucleus of the hypothalamus.

Pathogenic hypothalamic extracellular matrix promotes metabolic disease - Nature

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Extracellular Matrix Remodeling in the Hypothalamus Contributes to Metabolic Disorders
