Kernekoncepter
Black women in the United States have higher breast cancer mortality rates than White women across all tumor subtypes, with the greatest disparity observed in hormone receptor-positive (HR+), human epidermal growth factor 2–negative (HER2−) tumors.
Resumé
This article presents the findings of a systematic review and meta-analysis that examined racial differences in breast cancer (BC) survival by tumor subtype in the United States. The study included 18 studies published between 2009 and 2022, with a total of 228,885 women (34,262 Black women and 182,466 White women).
The key findings are:
- Black women had a higher risk of BC-specific death across all tumor subtypes compared to White women.
- The greatest disparity was observed in HR+ HER2− tumors, where Black women had a 50% higher risk of death.
- Black women also had a higher risk of death for HR+ HER2+ (34% higher), HR− HER2+ (20% higher), and HR− HER2− (17% higher) tumors.
- Overall survival was also poorer for Black women across all subtypes, although the estimates for HR− HER2+ tumors did not reach statistical significance.
- Adjustments for socioeconomic status and the proportion of Black participants explained about half and all the variance in the disparities for HR+ HER2− and HR− HER2+ tumors, respectively.
The authors conclude that there are both subtype-specific and subtype-independent mechanisms that contribute to the disparities in breast cancer survival between Black and White women, requiring multilevel interventions to address and achieve health equity.
Statistik
Black women had a 50% higher risk of death from hormone receptor-positive (HR+), human epidermal growth factor 2–negative (HER2−) breast cancer compared to White women (hazard ratio [HR], 1.50; 95% CI, 1.30-1.72).
Black women had a 34% higher risk of death from HR+ HER2+ breast cancer compared to White women (HR, 1.34; 95% CI, 1.10-1.64).
Black women had a 20% higher risk of death from HR− HER2+ breast cancer compared to White women (HR, 1.20; 95% CI, 1.00-1.43).
Black women had a 17% higher risk of death from HR− HER2− breast cancer compared to White women (HR, 1.17; 95% CI, 1.10-1.25).
Citater
"These results suggest there are both subtype-specific and subtype-independent mechanisms that contribute to disparities in breast cancer survival between Black and White women, which require multilevel interventions to address and achieve health equity."