The article introduces a novel method, Discrete Walk-Jump Sampling (dWJS), for efficient protein discovery. By combining energy-based and score-based models, the approach simplifies training and sampling processes. The method achieves high success rates in generating functional antibodies, outperforming existing models. The Distributional Conformity Score is introduced as a metric to evaluate sample quality. Experimental results demonstrate the effectiveness of dWJS in both in silico and in vitro settings.
Til et andet sprog
fra kildeindhold
arxiv.org
Vigtigste indsigter udtrukket fra
by Nathan C. Fr... kl. arxiv.org 03-19-2024
https://arxiv.org/pdf/2306.12360.pdfDybere Forespørgsler