The content discusses a novel approach to accessing high-energy carbene intermediates, which are valuable but often challenging to generate using classical methods. The key innovation is a metallaphotoredox platform that enables carbene formation through a two-step radical addition and redox-promoted α-elimination process.
The authors demonstrate the versatility of this strategy by showcasing its application to a range of carbene-mediated transformations, including cyclopropanation and σ-bond insertion into N–H, S–H, and P–H bonds. Importantly, these reactions can be carried out using abundant and bench-stable starting materials such as carboxylic acids, amino acids, and alcohols, overcoming the limitations of traditional carbene generation methods.
The content highlights how this metallaphotoredox approach represents a general solution to the challenge of harnessing carbene reactivity for complex molecule synthesis, enabling the construction of diverse molecular scaffolds from readily available feedstocks.
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by Benjamin T. ... a las www.nature.com 06-06-2024
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