Keskeiset käsitteet
Fiber supplement intake during pregnancy can reduce the risk of gestational diabetes and preterm birth in women with high insulin resistance.
Tiivistelmä
Researchers conducted a study on pregnant women with high insulin resistance to assess the impact of a fiber supplement on gestational diabetes and preterm birth.
Key Takeaways
- High insulin resistance women showed improved glucose metabolism and reduced risk of gestational diabetes and preterm birth with fiber supplement intake.
- The intervention did not affect lipid profiles or other outcomes.
Why This Matters
- Gestational diabetes poses risks for maternal and perinatal complications and future type 2 diabetes.
- High TyG index in early pregnancy is linked to gestational diabetes development.
- Enhancing glucose metabolism in high TyG index women may prevent gestational diabetes.
Study Design
- 295 women with a TyG index ≥ 8.5 before 20 weeks' gestation were randomly assigned.
- Women received oral dietary fiber powder or usual care during weeks 20-24.
- Participants underwent glucose tolerance tests and additional assessments.
Key Results
- Fiber supplement group had lower gestational diabetes incidence and blood glucose levels.
- No significant differences in other parameters between groups.
- Women receiving the supplement had longer gestational age and lower preterm birth rates.
Limitations
- Small sample size and single-center study.
- Short duration of the dietary fiber intervention.
Disclosures
- Study had no commercial funding.
- Authors had no disclosures.
Tilastot
"The incidence of gestational diabetes among women in the group who ingested the fiber supplement was 11.2%, significantly less than the 23.7% rate among women who served as controls."
"Mean gestational age at delivery among women who received the fiber supplement was 39.07 weeks, significantly greater than the 38.58-week average among the controls."
"The incidence of preterm delivery at less than 37 weeks was 2.3% among women who used the fiber supplement, significantly less than the 9.4% rate among the controls."
Lainaukset
"Improving glucose metabolism in women with a high TyG index during pregnancy might help prevent gestational diabetes."