מושגי ליבה
Chromatin interactions in ageing human brain cells impact gene expression and disease pathology.
תקציר
The content introduces the MUSIC technique for analyzing chromatin interactions, gene expression, and RNA associations in individual nuclei. It highlights the correlation between chromatin interactions, gene expression, and Alzheimer's disease pathology in older donors' frontal cortex samples. The study also reveals the impact of chromatin contacts on gene expression and the heterogeneous interactions between XIST non-coding RNA and chromosome X in female cortical cells.
סטטיסטיקה
Chromatin complex compositions change during cellular differentiation and ageing.
Nuclei with fewer short-range chromatin interactions correlate with an 'older' transcriptomic signature and Alzheimer's disease pathology.
Female cortical cells exhibit diverse interactions between XIST non-coding RNA and chromosome X.
ציטוטים
"MUSIC delineated diverse cortical cell types and states."
"Nuclei with fewer short-range chromatin interactions were correlated with both an 'older' transcriptomic signature and Alzheimer's disease pathology."