
Infralimbic parvalbumin (PV) neurons play a causal role in suppressing freezing behavior to enable flexible avoidance responses in threatening environments.


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The infralimbic cortex (IL) is essential for flexible behavioral responses to threatening environmental events. Reactive behaviors such as freezing or flight are adaptive in some contexts, but in others a strategic avoidance behavior may be more advantageous. IL has been implicated in avoidance, but the contribution of distinct IL neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we study IL parvalbumin (PV) interneurons in mice as they engage in active avoidance behavior, a behavior in which mice must suppress freezing in order to move to safety. We find that activity in inhibitory PV neurons increases during movement to avoid the shock in this behavioral paradigm, and that PV activity during movement emerges after mice have experienced a single shock, prior to learning avoidance. PV neural activity does not change during movement toward cued rewards or during general locomotion in the open field, behavioral paradigms where freezing does not need to be suppressed to enable movement. Optogenetic suppression of PV neurons increases the duration of freezing and delays the onset of avoidance behavior, but does not affect movement toward rewards or general locomotion. These data provide evidence that IL PV neurons support strategic avoidance behavior by suppressing freezing.

### Competing Interest Statement

The authors have declared no competing interest.

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

infralimbic-parvalbumin-neurons-facilitate-active-threat-avoidance-by-suppressing-freezing-behavior


Infralimbic Parvalbumin Neurons Facilitate Active Threat Avoidance by Suppressing Freezing Behavior
