Noncanonical Functions of ATG5 and Membrane Atg8ylation in Regulating Retromer Assembly and Cargo Sorting
ATG5 and the membrane atg8ylation machinery play a critical role in regulating the function of the retromer complex, which is responsible for sorting and trafficking of key cellular cargoes such as the glucose transporter GLUT1.
Identification of a Novel Essential Cell Division Protein Aeg1 in the Pathogenic Bacterium Acinetobacter baumannii
Aeg1 is a previously unrecognized core component of the Acinetobacter baumannii divisome that interacts with multiple cell division proteins, including FtsN, to recruit and activate the septal peptidoglycan synthase FtsWI.
Mitochondrial Stress Triggers Dynamic Stress Granule Formation and Disassembly to Maintain Organelle Homeostasis
Activation of the mitochondrial unfolded protein response (UPRmt) regulates the dynamic formation and disassembly of stress granules (SGs) to maintain mitochondrial homeostasis under stress conditions.
Targeted Microtubule-Based Transport Facilitates Ribbon Synapse Assembly in Developing Cochlear Inner Hair Cells
Ribbon precursors in inner hair cells utilize the polarized microtubule cytoskeleton and the anterograde motor Kif1a for targeted trafficking and structural plasticity to enable proper ribbon synapse assembly and maturation.
Phosphorylation of the C-terminus of the α-Arrestin Aly3 Regulates Glucose Transporter Ght5 Localization and Cell Proliferation in Fission Yeast under Low Glucose Conditions
Phosphorylation of the C-terminal serine residues of the α-arrestin Aly3 by the TORC2 pathway inhibits Aly3-mediated ubiquitination and vacuolar transport of the glucose transporter Ght5, thereby ensuring cell-surface localization of Ght5 and enabling cell proliferation under low glucose conditions in fission yeast.
Autophagy Protein ATG14 Safeguards Oviduct Function to Enable Embryo Transport During Early Pregnancy
ATG14 is critical for maintaining the structural integrity and cellular plasticity of the oviduct, preventing unscheduled pyroptosis activation, and enabling the timely transport of embryos from the oviduct to the uterus for successful implantation.
Microtubule-Dependent Orchestration of Centriole Amplification in Brain Multiciliated Cells
Microtubules organize the pericentrosomal nest from which procentrioles emerge, retain deuterosomes in a focused area, promote their maturation, and assist in the collective migration of centrioles to the apical membrane during multiciliated cell differentiation.
Ubiquitin-Specific Protease USP8 Regulates Endosome Maturation by Coordinating Rab5 and Rab7 GTPase Activation
USP8 is recruited to Rab5-positive early endosomes through its interaction with the Rab5 guanine nucleotide exchange factor Rabex5, and this recruitment dissociates Rabex5 from endosomes while promoting the recruitment of the Rab7 guanine nucleotide exchange factor SAND-1/Mon1, thereby facilitating the transition from Rab5-positive early endosomes to Rab7-positive late endosomes and lysosomes.
ESCRT Disruption Reveals Synaptic Exosomes Primarily Serve Proteostatic Functions, Not Intercellular Signaling
Disruption of ESCRT machinery leads to accumulation of exosome cargoes within presynaptic terminals, without depleting their signaling activities, suggesting synaptic exosomes primarily serve proteostatic functions rather than intercellular signaling.
The Actomyosin System is Essential for Maintaining the Complex Endosomal Architecture in Bloodstream Form Trypanosoma brucei
The actomyosin system, consisting of actin and the class I myosin TbMyo1, is essential for maintaining the complex three-dimensional architecture of the endosomal system in bloodstream form Trypanosoma brucei.
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