효소 반응 특이적 효소 촉매 포켓 생성: 흐름 매칭 및 공진화 동역학을 통한 접근
효소-기질 상호작용의 동적 화학 변환을 포착하기 위해 흐름 매칭 모델과 효소-반응 공진화를 결합하여 특정 기질 및 촉매 반응에 대한 효소 촉매 포켓을 생성합니다.
Generating Reaction-specific Enzyme Catalytic Pockets through Flow Matching and Co-Evolutionary Dynamics
EnzymeFlow, a generative model that employs flow matching with hierarchical pre-training and enzyme-reaction co-evolution, can generate catalytic pockets for specific substrates and catalytic reactions.
Radiomics and Gaze-guided Medical Image Generation using Diffusion Models
Integrating radiologists' eye gaze patterns and radiomic feature maps as controls to text-to-image diffusion models can generate high-fidelity and clinically accurate medical images.
Mapping the Complete Neural Wiring Diagram of the Fruit Fly Brain
The first complete mapping of the neural connections in the adult fruit fly brain, a landmark achievement that will transform the understanding of brain function.
神經退化性疾病中混合蛋白質纖維的意外發現
神經退化性疾病中首次發現由兩種不同蛋白質組成的疾病相關纖維,這為理解這些疾病的發病機制提供了線索。
신경퇴행성 질환에서 발견된 하이브리드 단백질 필라멘트의 놀라운 발견
신경퇴행성 질환에서 발견된 TDP-43과 ANXA11 단백질로 구성된 하이브리드 필라멘트의 구조적 특성
神経変性疾患における新発見の複合タンパク質フィラメント
神経変性疾患の原因となる異常に折りたたまれたタンパク質フィラメントは、従来単一のタンパク質から構成されると考えられていたが、TDP-43とANXA11の2種類のタンパク質から成る新しいタイプのフィラメントが発見された。
Discovery of Hybrid Protein Filaments in Neurodegenerative Diseases Challenges Previous Understanding
Neurodegenerative diseases are characterized by the aggregation of abnormally folded protein filaments in the brain, but a new study has identified the first disease-associated filament composed of two distinct proteins - TDP-43 and annexin A11.
LYCHOS는 식물 유사 PIN 수송체와 GPCR의 인간 하이브리드
LYCHOS는 콜레스테롤 센서 역할을 하는 리소좀 막단백질로, 식물 PIN 수송체와 GPCR 도메인이 융합된 독특한 구조를 가지고 있다.
Structural Insights into the Hybrid Transmembrane Protein LYCHOS, a Cholesterol Sensor Regulating Cellular Metabolism and Growth
LYCHOS is a unique hybrid transmembrane protein that combines a plant-like auxin transporter domain and a G-protein-coupled receptor (GPCR) domain to sense cholesterol and regulate the master metabolic regulator mTORC1.
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