
Glycosphingolipid synthesis is an essential pathway for cancer cells to evade the immune system, despite being dispensable for cancer cell proliferation.


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Functional genomics and lipidomic analyses reveal that sphingolipid synthesis is required for tumour immune evasion and tumour growth in vivo, mediated in part by the impact of glycosphingolipid synthesis on cell surface expression of IFNγ receptors.

Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer - Nature

glycosphingolipid-synthesis-a-critical-pathway-for-cancer-immune-evasion


Glycosphingolipid Synthesis: A Critical Pathway for Cancer Immune Evasion
