Ribosome Depletion and p53 Axis Activation Drive the Response of MLL-Rearranged Cancer Cells to WDR5 Inhibition
WIN site inhibitors of the chromatin-associated protein WDR5 induce depletion of the ribosome inventory, leading to a broad translational choke and activation of the p53-MDM4 axis, which drives apoptosis in MLL-rearranged cancer cells.