Grunnleggende konsepter
Substance use disorders share a common genetic signature, paving the way for personalized interventions and universal therapies.
Sammendrag
Substance use disorders (SUDs) like alcohol, tobacco, cannabis, and opioids have a common genetic signature, as per new research. The study aims to develop personalized interventions and universal therapies for treating multiple addictions.
Key Highlights:
- Genetics play a crucial role in determining health outcomes.
- Genomic studies aim to identify factors influencing substance use disorders.
- Understanding genetics can lead to tailored interventions.
- Research published in Nature Mental Health.
- Study involved over 150 investigators globally.
- Genome-wide association study identified genetic variations linked to SUDs.
- Strong gene signals related to dopamine system in addiction.
- Genomic patterns predict risks of mental and physical illnesses.
- Shared genetic mechanisms between substance use and mental disorders.
- Potential repurposing of drugs for treating SUDs.
Statistikk
"In a genome-wide association study (GWAS), the investigators looked for variations in the genome that were closely associated with SUDs in more than 1 million people of European ancestry and 92,630 people of African ancestry."
"Among the European ancestry sample, they discovered 19 single nucleotide polymorphisms (SNPs) that were significantly associated with general addiction risk and 47 genetic variants linked to specific SUDs — nine for alcohol, 32 for tobacco, five for cannabis, and one for opioids."
Sitater
"Genetics play a key role in determining health throughout our lives, but they are not destiny."
"A better understanding of genetics also brings us one step closer to developing personalized interventions that are tailored to an individual’s unique biology, environment, and lived experience."