Główne pojęcia
ADMarker is the first end-to-end system that integrates multi-modal sensors and new federated learning algorithms to accurately detect a comprehensive set of multidimensional digital biomarkers of Alzheimer's disease in a privacy-preserving manner.
Streszczenie
The paper presents ADMarker, a novel multi-modal federated learning system for monitoring digital biomarkers of Alzheimer's disease (AD). Key highlights:
ADMarker features a comprehensive set of 22 digital biomarkers related to basic activities of daily living, instrumental activities, and social interactions, which are strongly associated with different stages of AD.
ADMarker incorporates a compact multi-modality hardware system with depth camera, mmWave radar, and microphone to capture these digital biomarkers in a privacy-preserving manner.
ADMarker introduces a novel three-stage federated learning architecture that can accurately detect the digital biomarkers without sharing raw sensor data. The approach includes model pre-training, unsupervised multi-modal federated learning, and weakly supervised multi-modal federated learning.
The system was deployed in a 4-week clinical trial with 91 elderly participants, including 31 with AD and 30 with mild cognitive impairment (MCI). ADMarker can detect the digital biomarkers with up to 93.8% accuracy and identify early AD with 88.9% accuracy.
ADMarker offers a new platform that allows clinicians to monitor the progression of AD manifestations and study the complex correlation between multidimensional interpretable digital biomarkers, demographic factors, and AD diagnosis.
Statystyki
"ADMarker can detect a comprehensive set of daily activities in natural home environments with up to 93.8% detection accuracy."
"Leveraging the detected digital biomarkers, ADMarker can identify early AD with an average of 88.9% accuracy."
Cytaty
"ADMarker is the first end-to-end system that integrates multi-modal sensors and new federated learning algorithms for detecting multidimensional AD digital biomarkers in a privacy-preserving manner."
"The results show that ADMarker can accurately detect a comprehensive set of digital biomarkers and identify early AD with high accuracy."