
The FANCD2-FANCI protein complex is a sliding clamp that binds and diffuses on double-stranded DNA, but stalls at single-stranded to double-stranded DNA junctions, which are generated at stalled replication forks. This allows the complex to recognize sites of DNA damage and coordinate DNA repair.


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FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA&nbsp;but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the roles of FANCD2–FANCI in the recognition and protection of stalled replication forks.

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions - Nature

fancd2-fanci-complex-recognizes-double-stranded-to-single-stranded-dna-junctions-and-plays-a-central-role-in-dna-crosslink-repair-and-replication-fork-protection


FANCD2–FANCI Complex Recognizes Double-Stranded to Single-Stranded DNA Junctions and Plays a Central Role in DNA Crosslink Repair and Replication Fork Protection
