
Cells maintain an intermediate Rb-E2F activity state before committing to proliferation, allowing them to sense and respond to various signals.


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Cells actively sense external and internal signals to stay quiescent or proliferate, and this trigger relies on being in a reversible primed G1 state of partial retinoblastoma inactivation and E2F activation.

An intermediate Rb–E2F activity state safeguards proliferation commitment - Nature

intermediate-rb-e2f-activity-state-regulates-cell-proliferation-commitment


Intermediate Rb-E2F Activity State Regulates Cell Proliferation Commitment
