
抗癲癇藥物減量與大腦皮質區域日間 Delta 波段功率降低呈現劑量依賴性相關。


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抗癲癇藥物減量與大腦皮質日間-delta-波段功率降低的相關性


抗癲癇藥物減量與大腦皮質日間 Delta 波段功率降低的相關性


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人類皮質錐體細胞的生物物理特性在整個生命週期中發生顯著變化，特別是在生命的第一年和晚年，這些變化可能會影響大腦發育、認知功能和與年齡相關的神經退行性疾病。


The basic excitatory neurons of the cerebral cortex, the pyramidal cells, are the most important signal integrators for the local circuit. They have quite characteristic morphological and electrophysiological properties that are known to be largely constant with age in the young and adult cortex. However, the brain undergoes several dynamic changes throughout life, such as in the phases of early development and cognitive decline in the aging brain. We set out to search for intrinsic cellular changes in supragranular pyramidal cells across a broad age range: from birth to 85 years of age and we found differences in several biophysical properties between defined age groups. During the first year of life, subthreshold and suprathreshold electrophysiological properties changed in a way that shows that pyramidal cells become less excitable with maturation, but also become temporarily more precise. According to our findings, the morphological features of the three-dimensional reconstructions from different life stages showed consistent morphological properties and systematic dendritic spine analysis of an infantile and an old pyramidal cell showed clear significant differences in the distribution of spine shapes. Overall, the changes that occur during development and aging may have lasting effects on the properties of pyramidal cells in the cerebral cortex. Understanding these changes is important to unravel the complex mechanisms underlying brain development, cognition and age-related neurodegenerative diseases.

### Competing Interest Statement

The authors have declared no competing interest.

Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range

人類皮質淺層錐體細胞在廣泛年齡範圍內的電生理學和形態學研究


新的八點評分量表 SCORE，結合臨床指標和影像學檢查結果，能有效預測內側顳葉癲癇患者接受 SLAH 手術後的無 seizures  機率，為手術決策提供參考。


Easy-to-use scale helped clinicians identify which patients with medial temporal lobe epilepsy would achieve seizure freedom after stereotactic laser amygdalohippocampotomy.

8-Point Ordinal SCORE Scale Predicts SLAH Success

八點評分制-score-量表預測立體定向雷射杏仁核海馬迴切除術成功率


八點評分制 SCORE 量表預測立體定向雷射杏仁核海馬迴切除術成功率
