The study examined the risk of chronic kidney disease (CKD) following total thyroidectomy in a large cohort of Danish patients. The researchers found that the risk of CKD was two to three times higher in patients who underwent total thyroidectomy, compared to the general population. This risk was even higher in patients who developed hypoparathyroidism, a common complication of the surgery.
The study identified 2,421 patients who underwent total thyroidectomy between 1998 and 2017, and matched them with 24,210 individuals from the general population. Over a median follow-up of 5.5 years, the researchers found that the 10-year risk of CKD was 13.5% in patients with hypoparathyroidism and 11.6% in those without, compared to only 5.8% in the general population.
The increased risk of CKD was observed even in patients without prior comorbidities, suggesting that the thyroidectomy itself is a significant risk factor. The risk was highest in patients with a history of thyrotoxicosis, followed by those with goiter, but not for those with thyroid cancer.
The authors emphasize the importance of close monitoring and management of calcium and vitamin D levels in patients who undergo total thyroidectomy, especially those who develop hypoparathyroidism, to mitigate the risk of chronic kidney disease.
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by Edited Shrab... 於 www.medscape.com 08-27-2024
https://www.medscape.com/viewarticle/thyroid-surgery-increases-kidney-disease-risk-2024a1000fmd深入探究