Research on human lymphatic vessel development using 31 embryos and 3 fetuses revealed that Prox1-expressing lymphatic endothelial cells (LECs) originate from cardinal veins. LECs form initial lymph sacs around the veins, with varying rates of development and marker expression in different organs. The study highlights the diversity in lymphatic vessel development across organs and contributes to understanding lymph-related diseases. The emergence of lympho-venous valves between lymph sacs and veins was observed, crucial for normal lymphatic function. The study also explored the development of cardiac, lung, lower jaw, mesentery, intestinal, kidney, and thoracic duct lymphatic vessels at different stages. Notably, the research provides insights into the evolutionarily conserved processes of human lymphatic vessel formation.
翻译成其他语言
从原文生成
biorxiv.org
从中提取的关键见解
by Yamaguchi,S.... 在 www.biorxiv.org 08-15-2023
https://www.biorxiv.org/content/10.1101/2023.08.12.553102v2更深入的查询