
Buildup of a molecular meshwork around neurons in the arcuate nucleus of the hypothalamus blocks insulin signaling, leading to increased food intake, fat accumulation, and metabolic problems in obese mice.


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Neuronal insulin resistance caused by excess extracellular matrix.

Obesity is driven by a build-up of molecular mesh around hunger neurons

molecular-mesh-buildup-around-hunger-neurons-drives-obesity-in-mice


Molecular Mesh Buildup Around Hunger Neurons Drives Obesity in Mice


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腸道定植抵抗力的喪失會使潛在有害細菌大量入侵腸道,重建定植抵抗力是一個重要的臨床目標。腸道定常菌可以通過耗竭營養來抑制肺炎克雷伯氏菌等有害細菌的入侵。


Depletion of the molecule gluconate halts gut colonization by a pathogen.

Gut microbes fend off harmful bacteria by depriving them of nutrients

腸道微生物透過剝奪營養來抑制有害細菌的入侵


장내 상주 박테리아가 영양분 고갈을 통해 Klebsiella pneumoniae와 같은 유해 박테리아의 장내 정착을 억제한다.


장내-미생물이-영양분-고갈로-유해-박테리아를-막아내는-방식


장내 미생물이 영양분 고갈로 유해 박테리아를 막아내는 방식



腸内細菌は、栄養分の奪い合いによって、有害細菌の腸内への侵入を阻止する。


腸内細菌が有害細菌の侵入を阻止する仕組み-栄養分の奪い合い


腸内細菌が有害細菌の侵入を阻止する仕組み - 栄養分の奪い合い



Gut commensal bacteria suppress colonization by harmful pathogens like Klebsiella pneumoniae through nutrient depletion.


how-gut-microbes-prevent-harmful-bacteria-invasion-by-depriving-them-of-nutrients


How Gut Microbes Prevent Harmful Bacteria Invasion by Depriving Them of Nutrients



視丘神經元外基質的病理性重塑是導致代謝性疾病的根本機制。


Experiments in mice show that the perineural net has a key role in metabolic disease by controlling insulin access to neurons in the arcuate nucleus of the hypothalamus.

Pathogenic hypothalamic extracellular matrix promotes metabolic disease - Nature

肥胖和代謝性疾病的根源-視丘神經元外基質的病理性改變


肥胖和代謝性疾病的根源:視丘神經元外基質的病理性改變



대사 질환에서 시상하부 아급핵 신경세포를 둘러싼 특수 세포외기질인 페리뉴런 네트워크의 변화가 인슐린 저항성과 대사 기능 장애를 유발한다.


대사-질환을-유발하는-시상하부-세포외기질의-역할


대사 질환을 유발하는 시상하부 세포외기질의 역할



Remodeling of the specialized extracellular matrix, termed perineuronal net, surrounding neurons in the arcuate nucleus of the hypothalamus drives insulin resistance and metabolic dysfunction in obesity and type 2 diabetes.


extracellular-matrix-remodeling-in-the-hypothalamus-contributes-to-metabolic-disorders


Extracellular Matrix Remodeling in the Hypothalamus Contributes to Metabolic Disorders



The Sahara Desert, once a lush and verdant landscape, has undergone a dramatic transformation over time, transitioning from a habitable region to the arid expanse we know today.


A series of scientific discoveries tell us a story that not everybody knows about the Sahara Desert

When The Sahara Wasn’t a Desert

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The Sahara Desert's Surprising Past: From Lush Landscape to Arid Expanse



단백질 위치 재배치를 통해 질병 유발 표현형을 해결할 수 있는 새로운 표적 치료법 제시


Targeted protein relocalization using shuttle proteins with potent ligands amenable to incorporation into targeted relocalization activating molecules could be used to regulate cellular physiology and correct disease states in neurodegenerative diseases, cancer and genetic disorders.

Targeted protein relocalization via protein transport coupling - Nature

단백질-수송-결합을-통한-표적-단백질-재배치


단백질 수송 결합을 통한 표적 단백질 재배치
