
녹내장 관련 옵티뉴린 돌연변이는 시신경 축삭 내에서 정지된 미토콘드리아와 미토파지 기구의 증가를 유발하며, 이는 축삭 외부로 방출된 미토콘드리아의 성상세포에 의한 분해로 이어진다.


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We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large- effect glaucoma genes and axonal damage occurs at the optic nerve head in glaucoma, here we explored whether OPTN mutations perturb transmitophagy. Live-imaging of Xenopus laevis optic nerves revealed that diverse human mutant but not wildtype OPTN increase stationary mitochondria and mitophagy machinery and their colocalization within, and in the case of the glaucoma-associated OPTN mutations also outside of, RGC axons. These extra-axonal mitochondria are degraded by astrocytes. Our studies support the view that in RGC axons under baseline conditions there are low levels of mitophagy, but that glaucoma-associated perturbations in OPTN result in increased axonal mitophagy involving the shedding and astrocytic degradation of the mitochondria.

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### Competing Interest Statement

The authors have declared no competing interest.

 [1]: pending:yes

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve

녹내장-관련-옵티뉴린-돌연변이는-척추동물-시신경에서-전달미토파지를-증가시킨다


녹내장 관련 옵티뉴린 돌연변이는 척추동물 시신경에서 전달미토파지를 증가시킨다
