
Buildup of a molecular meshwork around neurons in the arcuate nucleus of the hypothalamus blocks insulin signaling, leading to increased food intake, fat accumulation, and metabolic problems in obese mice.


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Neuronal insulin resistance caused by excess extracellular matrix.

Obesity is driven by a build-up of molecular mesh around hunger neurons

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Molecular Mesh Buildup Around Hunger Neurons Drives Obesity in Mice
