Identification and Characterization of PITAR, a DNA Damage-Inducible Long Noncoding RNA that Inhibits p53 by Stabilizing TRIM28 mRNA in Glioblastoma
PITAR, a long noncoding RNA, inhibits p53 by binding and stabilizing TRIM28 mRNA, which encodes a p53-specific E3 ubiquitin ligase, thereby promoting p53 ubiquitination and degradation.