Kernekoncepter
Overweight and obesity in individuals with familial hypercholesterolemia (FH) significantly increase the risk of coronary artery disease.
Resumé
The content discusses a registry analysis that reveals individuals with FH have rates of overweight and obesity similar to the general population, impacting their risk of coronary artery disease. The study emphasizes the importance of weight management alongside lipid-lowering medication for FH patients. Key insights include:
- Rates of overweight and obesity in FH patients mirror the general population.
- Overweight or obesity significantly increase the risk of coronary artery disease, especially in heterozygous FH patients.
- Weight management is crucial for FH patients to reduce the risk of coronary artery disease.
- The study highlights the need for a holistic approach to patient care, focusing on weight management alongside lipid-lowering medication.
Statistik
Data on almost 36,000 individuals with FH were analyzed.
55% of adults with heterozygous FH had overweight or obesity.
Adults with obesity faced a twofold increased risk of coronary artery disease.
Children and adolescents with heterozygous FH and obesity had a more than sixfold increased risk of coronary artery disease.
Levels of LDL and remnant cholesterol were significantly associated with BMI in FH patients.
Having obesity was associated with a substantial increase in the risk of coronary artery disease among patients with heterozygous FH.
Citater
"Obesity is associated with a worse lipid profile, even from childhood, regardless of whether a patient is on medication." - Amany Elshorbagy
"If a risk factor such as obesity is added 'on top of the strongest risk factor, that is LDL cholesterol, it is not one plus one makes two, it is one plus one makes three." - Alberico L. Catapano