Kernekoncepter
The presence and location of lobar cerebral microbleeds in individuals with Alzheimer's disease are significantly associated with accelerated cognitive decline, particularly in semantic and language domains, and correlate with increased amyloid and tau pathology, suggesting their potential as a prognostic marker.
Statistik
Of the 1,573 participants, 1200 (76%) had no microbleeds, whereas 373 (24%) had at least one microbleed.
89% of subjects with microbleeds had at least one lobar microbleed.
The prevalence of microbleeds was 24.0% (373 participants).
Microbleeds in the temporal lobe were linked to declines in the semantic (coefficient = 0.73; 95% CI, 0.02 to 0.10; P=.004), language (coefficient = 0.16; 95% CI, 0.03 to 0.28; P=0.013), and praxis domains (coefficient = 0.09; 95% CI, 0.00 to 0.18; P=0.039).
Microbleeds in the overall cortex were associated with a decline in the language domain (coefficient = 0.10; 95% CI, 0.02 to 0.18; P = 0.018).