
Type I interferon opposes the AHR-JUN axis to promote the expansion of CXCL13-producing T follicular helper and T peripheral helper cells, contributing to the pathogenesis of systemic lupus erythematosus.


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Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus - Nature

interferon-disrupts-ahr-jun-axis-to-induce-cxcl13-producing-t-cells-in-systemic-lupus-erythematosus


Interferon Disrupts AHR-JUN Axis to Induce CXCL13-Producing T Cells in Systemic Lupus Erythematosus
