Kernkonzepte
First-line osimertinib for EGFR-mutated NSCLC patients during COVID-19 showed efficacy and safety, with notable outcomes and challenges.
Zusammenfassung
Abstract and Introduction
FLAURA trial improved OS with first-line osimertinib for EGFR-mutated NSCLC.
Study assessed osimertinib efficacy and safety during the COVID-19 pandemic.
Identified patients in British Columbia, Canada, from March 2020 to December 2021.
Analyzed OS, PFS, baseline characteristics, and adverse events.
Pneumonitis and dose reductions' impact on OS evaluated.
231 individuals in the cohort, with significant findings on patient demographics and outcomes.
Results
58.7% of patients diagnosed with de novo advanced NSCLC in the Emergency Room.
Median PFS was 18.0 months, and OS was 25.4 months.
Factors like age, ECOG PS, smoking status, and mutation type influenced PFS.
33.6% of progressed patients received subsequent therapy.
16.5% developed grade ≥3 adverse events, with 3.9% incidence of pneumonitis.
10.8% of patients developed COVID-19.
Conclusions
ECOG PS ≥2 in half of patients led to shorter OS than FLAURA.
Low incidence of severe adverse events, and dose reductions did not affect OS.
Emphasized the need to address barriers to NSCLC diagnosis during COVID-19.
Introduction
EGFR TKIs improved prognosis for advanced NSCLC patients.
Osimertinib demonstrated superior outcomes in FLAURA trial.
Knowledge gaps exist in real-world efficacy and safety of osimertinib.
Study aimed to evaluate survival outcomes and prognostic factors during COVID-19.
Statistiken
Median PFS: 18.0 months [95% CI: 16.1–26.2]
Median OS: 25.4 months (95% CI: 20.3–not reached)
Pneumonitis incidence: 3.9%
Hazard ratio for pneumonitis impact on OS: 2.59, 95% CI: 0.94–7.12, P=0.066
COVID-19 incidence: 10.8%
Zitate
"Identifying and reducing barriers to the diagnosis of NSCLC during the COVID-19 pandemic are required."
"ECOG PS ≥2 was observed in nearly half of patients at treatment initiation contributing to a median OS shorter than in FLAURA."