Kernkonzepte
Recent trials and guidelines support shorter antibiotic courses for pediatric pneumonia treatment.
Statistiken
"EPIC was based in the United States. PERCH was an international study."
"Respiratory syncytial virus is one of the most common, and human rhinovirus is also very common."
"In the EPIC study, very few children had pneumococcus detected — less than 5% — similar to the PERCH study."
"In the SCOUT-CAP trial, short-course therapy was actually superior to the standard-course therapy."
"We saw similar clinical outcomes, but we achieved this with shorter durations in the short-course arm."
"We looked at antibiotic resistance genes about 2 weeks after stopping therapy, and for total resistance genes as well as beta-lactam resistance genes, we saw fewer resistance genes in the short-course arm compared to the long-course arm."
Zitate
"Short-course therapy was actually superior to the standard-course therapy."
"Short courses of therapy are effective in the outpatient setting for children with uncomplicated pneumonia."
"The Holy Grail here is how can we can limit antibiotic use in children who don't have bacterial disease?"