Conceptos Básicos
Disruption in delta wave activity during sleep, as measured by lower delta wave entropy, is associated with higher risk of coronary heart disease, cardiovascular disease, and cardiovascular mortality.
Resumen
The study examined delta wave activity during sleep in two large cohorts - the Sleep Heart Health Study (SHHS) and the Osteoporotic Fractures in Men Study Sleep study (MrOS).
Key findings:
- In the SHHS cohort, over 11 years of follow-up, 729 participants had incident cardiovascular disease and 192 died from cardiovascular causes.
- In the MrOS cohort, over 15.5 years of follow-up, 547 participants had incident cardiovascular disease and 391 died from cardiovascular causes.
- Lower delta wave entropy, indicating disrupted delta wave activity, was associated with higher risk of coronary heart disease, cardiovascular disease, and cardiovascular mortality in both cohorts, even after adjusting for other factors.
- Delta wave entropy outperformed traditional measures of sleep quality in predicting long-term cardiovascular risk.
The researchers suggest that low delta wave entropy, a marker of disrupted deep sleep, may represent a promising indicator of cardiovascular disease risk that could be implemented in clinical sleep medicine software. Further research is needed to understand the causal mechanisms and potential for interventions targeting delta wave activity to improve cardiovascular health.
Estadísticas
In the SHHS cohort, there were 729 incidents of cardiovascular disease and 192 cardiovascular deaths over 11 years of follow-up.
In the MrOS cohort, there were 547 incidents of cardiovascular disease and 391 cardiovascular deaths over 15.5 years of follow-up.
Lower delta wave entropy was associated with higher risk of coronary heart disease (SHHS: HR 1.46, MrOS: HR 1.79), cardiovascular disease (SHHS: HR 1.60, MrOS: HR 1.43), and cardiovascular mortality (SHHS: HR 1.94, MrOS: HR 1.66).
Citas
"Low delta wave entropy, a hallmark of disrupted delta wave activity, may represent a promising marker for disrupted activity of deep sleep."
"Disturbed delta wave activity may also represent a modifiable risk factor for cardiovascular disease."