Conceptos Básicos
Specific microbes in young-onset colorectal cancer differ from average-onset, impacting diagnosis and treatment.
Estadísticas
Patients with yoCRC vs aoCRC: left-sided tumors (72.8% vs 54.3%), rectal tumors (36.7% vs 25%), stage IV tumors (28% vs 15%).
yoCRC tumors had higher microbial alpha diversity.
Fusobacterium and Akkermansia abundance correlated with overall survival in yoCRC.
Citas
"[O]ur findings help to comprehensively define the microbial community that may play a role in young-onset colorectal oncogenesis [and] should encourage the evaluation of environmental and lifestyle risk factors that might contribute to microbial dysbiosis in this patient population." - Authors