Keskeiset käsitteet
Exposure to PM 2.5 does not link to dementia through stroke or hypertension.
Tiivistelmä
TOPLINE:
Stroke and hypertension are not mediators of the association between PM 2.5 and dementia.
More research is needed on how air pollution affects dementia risk.
METHODOLOGY:
Study hypothesized vascular dysfunction as a mediator but found no significant association.
27,857 participants from a nationally representative cohort were included.
PM 2.5 concentrations were estimated based on residential addresses.
TAKEAWAY:
14.7% of participants developed dementia after a mean follow-up of 10.2 years.
PM 2.5 levels were not associated with increased risk of stroke or hypertension.
IN PRACTICE:
Further investigation into the pathways linking air pollution to dementia is necessary.
Identifying populations benefiting most from pollution reduction strategies is crucial.
SOURCE:
Study conducted by Boya Zhang, PhD, University of Michigan School of Public Health.
Published in JAMA Network Open on September 20.
LIMITATIONS:
Use of 10-year average exposure may have underestimated the association.
Estimating PM 2.5 levels from residential history could introduce measurement error.
DISCLOSURES:
Study funded by NIA, Social Security Administration, and NIH.
No relevant financial relationships disclosed by Zhang.
Tilastot
"After a mean follow-up of 10.2 years, 14.7% of study participants developed dementia."
"Higher levels of PM 2.5 were not associated with increased risk of stroke."
"There was no association of PM 2.5 with prevalent hypertension."