
在白化病小鼠中，錯誤連接到視丘錯誤區域的視網膜神經節細胞軸突會形成突觸分離的子迴路，這表明活動依賴性突觸重塑在視覺迴路組織中的作用。


coremsg

A Hebbian model of circuit remodeling predicts that two sets of inputs with sufficiently distinct activity patterns will synaptically capture separate sets of target cells. Mice in which a subset of retinal ganglion cells (RGCs) target the wrong region of the dorsal lateral geniculate nucleus (dLGN) provide the conditions for testing this prediction. In albino mice, mistargeted RGC axons form an island of terminals that is distinct from the surrounding neuropil. Blocking retinal activity during development prevents the formation of this island. However, the synaptic connectivity of the island was unknown. Here, we combine light and electron microscopy to determine if this activity-dependent island of axon terminals represent a synaptically segregated subcircuit. We reconstructed the microcircuitry of the boundary between the island and non-island RGCs and found a remarkably strong segregation within retinogeniculate connectivity. We conclude that, when sets of retinal input are established in the wrong part of the dLGN, the developing circuitry responds by forming a synaptically isolated subcircuit from the otherwise fully connected network. The fact that there is a developmental starting condition that can induce a synaptically segregated microcircuit has important implications for our understanding of the organization of visual circuits and for our understanding of the implementation of activity dependent development.

### Competing Interest Statement

The authors have declared no competing interest.

Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice

白化病小鼠視丘中錯誤連接的視網膜軸突形成突觸分離的子迴路