
시냅스 다양성은 신경 회로의 복잡하고 적응 가능한 통신을 가능하게 하는 특징이다. 전압 의존성 칼슘 채널의 양, 공간 조직화, 아단위 구성이 시냅스 다양성에 기여한다.


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Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it is thus critical to determine the factors that contribute to the functional diversity of synapses. We investigated the contributions of voltage-gated calcium channel (VGCC) abundance, spatial organization, and subunit composition to synapse diversity among and between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter release probabilities (Pr). Surprisingly, VGCC levels are highly predictive of heterogeneous Pr among individual synapses of either low- or high-Pr inputs, but not between inputs. We find that the same number of VGCCs are more densely organized at high-Pr synapses, consistent with tighter VGCC-synaptic vesicle coupling. We generated endogenously tagged lines to investigate VGCC subunits in vivo and found that the α2δ-3 subunit Straightjacket along with the CAST/ELKS active zone (AZ) protein Bruchpilot, both key regulators of VGCCs, are less abundant at high-Pr inputs, yet positively correlate with Pr among synapses formed by either input. Consistently, both Straightjacket and Bruchpilot levels are dynamically increased across AZs of both inputs when neurotransmitter release is potentiated to maintain stable communication following glutamate receptor inhibition. Together, these findings suggest a model in which VGCC and AZ protein abundance intersects with input-specific spatial and molecular organization to shape the functional diversity of synapses.

### Competing Interest Statement

The authors have declared no competing interest.

Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

운동-신경-아형-간-및-내부의-분자적-및-조직적-다양성이-기능적-시냅스-이질성을-생성한다


운동 신경 아형 간 및 내부의 분자적 및 조직적 다양성이 기능적 시냅스 이질성을 생성한다
