
아동기 및 청소년기의 복잡한 구조적, 기능적 변화로 인해 정신병리 발달 위험을 이해하기 위해서는 다차원적 접근이 필요하다. 이 연구는 청소년 뇌 인지 발달 데이터셋에서 정신병리 차원과 관련된 구조적 및 기능적 뇌 네트워크 패턴을 동시에 조사하였다.


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Complex structural and functional changes occurring in typical and atypical development necessitate multidimensional approaches to better understand the risk of developing psychopathology. Here, we simultaneously examined structural and functional brain network patterns in relation to dimensions of psychopathology in the Adolescent Brain Cognitive Development dataset. Several components were identified, recapitulating the psychopathology hierarchy, with the general psychopathology ( p ) factor explaining most covariance with multimodal imaging features, while the internalizing, externalizing, and neurodevelopmental dimensions were each associated with distinct morphological and functional connectivity signatures. Connectivity signatures associated with the p factor and neurodevelopmental dimensions followed the sensory-to-transmodal axis of cortical organization, which is related to the emergence of complex cognition and risk for psychopathology. Results were consistent in two separate data subsamples, supporting generalizability, and robust to variations in analytical parameters. Our findings help in better understanding biological mechanisms underpinning dimensions of psychopathology, and could provide brain-based vulnerability markers.

### Competing Interest Statement

The authors have declared no competing interest.

아동 정신병리의 다중 양상 신경 상관관계