
HairSplitter는 어셈블리와 장기 리드를 사용하여 하플로타입을 효율적으로 분리할 수 있는 새로운 소프트웨어이다.


coremsg

Motivation Long-read assemblers face challenges in discerning closely related viral or bacterial strains, often collapsing similar strains in a single sequence. This limitation has been hampering metagenome analysis, where diverse strains may harbor crucial functional distinctions.

Results We introduce a novel software, HairSplitter, designed to retrieve strains from a strain-oblivious assembly and long reads. The method uses a custom variant calling process to operate with erroneous long reads and introduces a new read binning algorithm to recover an a priori unknown number of strains. On noisy long reads, HairSplitter can recover more strains while being faster than state-of-the-art tools, both in the viral and the bacterial case.

Availability HairSplitter is freely available on GitHub at [github.com/RolandFaure/HairSplitter][1].

Contact roland.faure{at}irisa.fr

### Competing Interest Statement

The authors have declared no competing interest.

 [1]: https://github.com/RolandFaure/Hairsplitter

HairSplitter: haplotype assembly from long, noisy reads

장기-노이즈-리드에서-하플로타입-어셈블리-hairsplitter


장기 노이즈 리드에서 하플로타입 어셈블리 - HairSplitter
