
UNC-6/네트린과 UNC-40/DCC는 축삭의 국소 접착과 방향성 성장을 모두 매개한다.


coremsg

During development axons undergo long-distance migrations as instructed by guidance molecules and their receptors, such as UNC-6/Netrin and UNC-40/DCC. Guidance cues act through long-range diffusive gradients (chemotaxis) or local adhesion (haptotaxis). However, how these discrete modes of action guide axons in vivo is poorly understood. Using time-lapse imaging of axon guidance in C. elegans , we demonstrate that UNC-6 and UNC-40 are required for local adhesion to an intermediate target and subsequent directional growth. Exogenous membrane-tethered UNC-6 is sufficient to mediate adhesion but not directional growth, demonstrating the separability of haptotaxis and chemotaxis. This conclusion is further supported by the endogenous UNC-6 distribution along the axon’s route. The intermediate and final targets are enriched in UNC-6 and separated by a ventrodorsal UNC-6 gradient. Continuous growth through the gradient requires UNC-40, which recruitsUNC-6 to the growth cone tip. Overall, these data suggest that UNC-6 stimulates stepwise haptotaxis and chemotaxis in vivo .

### Competing Interest Statement

The authors have declared no competing interest.

UNC-6/Netrin promotes both adhesion and directed growth within a single axon

unc-6-네트린은-단일-축삭-내에서-접착과-방향성-성장을-모두-촉진한다


UNC-6/네트린은 단일 축삭 내에서 접착과 방향성 성장을 모두 촉진한다
