The study focuses on the essential role of Slu7 in Cryptococcus neoformans for proper nuclear positioning during mitosis. Depletion of Slu7 leads to defects in cell cycle progression, including aberrant nuclear migration and spindle mispositioning. The findings suggest that Slu7 regulates the splicing of specific introns, impacting the expression of genes involved in cell cycle regulation and cytoskeletal components.
The research highlights the importance of splicing factors like Slu7 in coordinating gene expression for timely cell cycle transitions and nuclear division. The study provides insights into the molecular mechanisms underlying nuclear migration defects observed in Slu7-depleted cells. Further investigations are needed to understand the broader implications of RNA splicing on cell cycle progression and genome stability.
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biorxiv.org
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by Krishnan,V. ... ב- www.biorxiv.org 11-23-2023
https://www.biorxiv.org/content/10.1101/2023.11.23.568425v2שאלות מעמיקות