
RGS10 결핍은 상피-간엽 전환을 유도하여 유방암의 원격 전이를 촉진한다.


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Distant metastasis is the major cause of death in patients with breast cancer. Epithelial–mesenchymal transition (EMT) contributes to breast cancer metastasis. Regulator of G protein-signaling (RGS) proteins modulate metastasis in various cancers. This study identified a novel role for RGS10 in EMT and metastasis in breast cancer. RGS10 protein levels were significantly lower in breast cancer tissues compared to normal breast tissues, and deficiency in RGS10 protein predicted a worse prognosis in patients with breast cancer. RGS10 protein levels were lower in the highly aggressive cell line MDA-MB-231 than in the poorly aggressive, less invasive cell lines MCF7 and SKBR3. Silencing RGS10 in SKBR3 cells enhanced EMT and caused SKBR3 cell migration and invasion. The ability of RGS10 to suppress EMT and metastasis in breast cancer was dependent on lipocalin-2 and miR-539-5p. These findings identify RGS10 as a tumor suppressor, prognostic biomarker, and potential therapeutic target for breast cancer.

### Competing Interest Statement

The authors have declared no competing interest.

RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

유방암-전이에-rgs10-결핍이-기여한다-상피-간엽-전환-유도


유방암 전이에 RGS10 결핍이 기여한다: 상피-간엽 전환 유도
