Mechanism of BRCA1-BARD1 Complex in Regulating DNA End Resection and Protecting DNA Integrity

The BRCA1-BARD1 complex plays a dual role in DNA repair - it directly promotes long-range DNA end resection to initiate homologous recombination, while also protecting DNA from unscheduled degradation during replication stress, with the balance between these functions determined by the presence and concentration of the recombinase RAD51.