
LYCHOS is a unique hybrid transmembrane protein that combines a plant-like auxin transporter domain and a G-protein-coupled receptor (GPCR) domain to sense cholesterol and regulate the master metabolic regulator mTORC1.


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Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the transporter domain is similar to the plant PIN family.

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR - Nature

structural-insights-into-the-hybrid-transmembrane-protein-lychos-a-cholesterol-sensor-regulating-cellular-metabolism-and-growth


Structural Insights into the Hybrid Transmembrane Protein LYCHOS, a Cholesterol Sensor Regulating Cellular Metabolism and Growth
