
Transferrin receptor targeting chimeras (TransTACs) can efficiently degrade a diverse range of membrane proteins, enabling reversible control of primary cells and targeting drug-resistant cancers.


coremsg

Transferrin receptor targeting chimeras have been developed that enable targeting of drug resistance in epidermal growth factor receptor-driven lung cancer and reversible control of human primary chimeric antigen receptor T cells, representing a promising new family of bifunctional antibodies for targeted cancer therapy.

Transferrin receptor targeting chimeras for membrane protein degradation - Nature

transferrin-receptor-targeting-chimeras-a-novel-approach-for-efficient-membrane-protein-degradation-and-targeted-cancer-therapy


Transferrin Receptor Targeting Chimeras: A Novel Approach for Efficient Membrane Protein Degradation and Targeted Cancer Therapy
