Alapfogalmak
A highly pathogenic H5N1 avian influenza virus isolated from infected cow milk in the US exhibited systemic spread and tropism in mice and ferrets, as well as the ability to bind to human upper airway receptors, suggesting potential for increased mammalian infection and transmission.
Kivonat
The content describes the characterization of a highly pathogenic H5N1 avian influenza (HPAI H5N1) virus isolated from infected cow milk during an unprecedented outbreak in the US in 2024. The virus was found to spread systemically, including to the mammary glands, in both mice and ferrets, similar to an older HPAI H5N1 virus isolate. Importantly, the bovine HPAI H5N1 virus was also able to bind to sialic acids expressed in human upper airways, and it exhibited inefficient transmission to exposed ferrets, with one out of four ferrets seroconverting without detectable virus. These findings suggest that the bovine HPAI H5N1 virus possesses features that may facilitate increased infection and transmission in mammals, posing a potential public health risk.
Statisztikák
One out of four exposed ferrets seroconverted without virus detection.
Idézetek
"Bovine HPAI H5N1 virus thus possesses features that may facilitate infection and transmission in mammals."