Alapfogalmak
Endurance exercise training induces widespread multi-omic changes across multiple tissues, revealing insights into the adaptive responses that promote whole-body health.
Kivonat
This study presents a comprehensive multi-omic analysis of the temporal adaptations to endurance exercise training in male and female rats. The researchers profiled the transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome, and immunome in 19 tissues over 4 time points during an 8-week training program.
Key insights from the study:
- Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues.
- Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response, and mitochondrial pathways.
- Many of the observed changes are relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health, and tissue injury and recovery.
- The data and analyses presented in this study provide valuable resources for understanding the multi-tissue molecular effects of endurance training, which are made publicly available.
Statisztikák
The study profiled 9,466 assays across 19 tissues, 25 molecular platforms, and 4 training time points.
Idézetek
"Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood."
"The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points."
"Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery."