Alapfogalmak
Dietary inorganic nitrates effectively reduce contrast-induced nephropathy in ACS patients.
Kivonat
The NITRATE-CIN Study presented by Dr. Dan Jones at the ESC Congress 2023 in Amsterdam showcased the benefits of dietary inorganic nitrates in preventing contrast-induced nephropathy (CIN) in non-ST segment elevation myocardial infarction acute coronary syndrome (ACS) patients. The study highlighted a significant reduction in CIN, periprocedural myocardial infarction, and improved renal function with the use of dietary nitrates. The potential implications of this study in reducing complications of coronary angiography were discussed, emphasizing the need for further research and development of commercial products for wider use.
Key Highlights:
- Dietary inorganic nitrates show promise in preventing CIN.
- Reduction in periprocedural myocardial infarction and improved renal function.
- Significant decrease in major adverse cardiovascular and kidney events.
- Potential benefits of dietary nitrates in various health aspects.
- Plans for larger multicenter trials and commercial product development.
Statisztikák
"In the NITRATE-CIN Study, non-ST segment elevation myocardial infarction acute coronary syndrome (ACS) patients at risk of renal injury from coronary angiography who received dietary inorganic nitrates had a 70% reduction in CIN compared with those given placebo."
"Results showed that this primary CIN endpoint was reduced significantly from 30% in the placebo arm to 9.1% in the nitrate group, a 70% relative risk reduction (P < .0001)."
"Rates of procedural MI, a prespecified secondary endpoint, were reduced from 12.5% to 4.1% in those on inorganic nitrates (P = .003)."
Idézetek
"Currently, aside from intravenous hydration, there is no proven treatment that reduces contrast-induced nephropathy." - Dr. Dan Jones
"We're all going to get on beet juice after this." - Dr. Roxanna Mehran
"There appears to be many benefits of dietary nitrates, and the one thing we can do at this time is to encourage people to increase their dietary nitrate consumption by eating large quantities of green leafy vegetables and beetroot." - Dr. Dan Jones