
Adenosine signaling through astrocytic A2B receptors activates astrocyte glucose metabolism and lactate release, which is essential for supporting neuronal energy demands and maintaining synaptic function, sleep, and memory.


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This study explores how adenosine A2B receptors can act as astrocytic sensors&nbsp;of brain metabolic activity and how cAMP signalling in astrocytes may support core brain functions&nbsp;such as sleep and memory.

Adenosine signalling to astrocytes coordinates brain metabolism and function - Nature

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Adenosine Signaling Coordinates Astrocyte-Mediated Brain Metabolism and Function
