
A γδ T cell-derived cytokine, IL-3, acts on sensory neurons to lower their activation threshold to allergens, thereby promoting the initiation of allergic immune responses.


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A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses to allergens on first exposure.

A γδ T cell–IL-3 axis controls allergic responses through sensory neurons - Nature

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Uncovering the Immune-Neuronal Axis Controlling Allergic Responses: A γδ T Cell–IL-3 Signaling Pathway Regulates Sensory Neuron Activation by Allergens
