Propofol Restores Voltage-Dependent Gating in HCN1 Channel Epilepsy Mutations
Propofol, a general anesthetic, inhibits HCN1 channels by binding to a specific site between the S5 and S6 transmembrane helices, and can restore voltage-dependent closing in two HCN1 epilepsy-associated polymorphisms that destabilize the channel's closed state.