Konsep Inti
Combining exercise and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is the most effective weight loss strategy while preserving bone health in adults with obesity.
Abstrak
The study examined the effects of exercise, GLP-1 RAs (liraglutide), and their combination on weight loss and bone health in adults with obesity. Participants were initially placed on a low-calorie diet for 8 weeks, and those who lost at least 5% of their starting weight were then divided into four groups: exercise only, liraglutide only, combination of both, and placebo.
The key findings are:
- The combination group achieved the greatest weight loss of 16.88 kg over 52 weeks, compared to 7.03 kg in the placebo group, 11.19 kg in the exercise group, and 13.74 kg in the liraglutide group.
- The combination group maintained weight loss and even lost additional weight, while the placebo group regained weight, and the exercise and liraglutide groups maintained their weight loss.
- Bone mineral density (BMD) did not change in the combination group compared to the placebo group at the hip and spine, indicating that the combination of exercise and GLP-1 RAs preserved bone health during weight loss.
- In contrast, the liraglutide group showed decreases in BMD of the spine compared to the exercise and placebo groups, as well as decreases in the hip.
The study suggests that the combination of exercise and GLP-1 RAs is the most effective strategy for achieving significant weight loss while preserving bone health in adults with obesity.
Statistik
The overall average change in weight loss over the course of 52 weeks was 7.03 kg in the placebo group, 11.19 kg in the exercise group, 13.74 kg in the liraglutide group, and 16.88 kg in the combination group.
BMD did not change in the combination group in comparison to the placebo group at the hip (mean change, −0.006 g/cm2; 95% CI, −0.017 to 0.004 g/cm2; P = .24) or spine (−0.010 g/cm2; 95% CI, −0.025 to 0.005 g/cm2; P = .20).
BMD of the spine in the liraglutide group decreased in comparison to the exercise group (mean change, −0.016 g/cm2; 95% CI, −0.032 to −0.001 g/cm2; P = .04) and the placebo group, in addition to decreases in the hip.
Kutipan
"Our results show that the combination of exercise and GLP-1 RA was the most effective weight loss strategy while preserving bone health."