The content explores how metabolic perturbations influence the differentiation of human hematopoietic cells. By inducing transient changes in key metabolic reactions, the study observed alterations in chromatin structure, gene expression, and cell phenotype. These findings suggest a direct link between cellular metabolism and the differentiation process, highlighting the importance of energy optimization for cell survival and function.
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biorxiv.org
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by Racine,L., P... at www.biorxiv.org 09-17-2023
https://www.biorxiv.org/content/10.1101/2023.09.17.558120v2Deeper Inquiries